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BOOK SUMMARY :

While efflux via abc transporters is a normal physiological process it is also a known mechanism of drug resistance in cancer cells three transportersmultidrug resistance protein 1 mdr1 multidrug resistance associated protein 1 mrp1 and breast cancer resistance protein bcrpare implicated in many drug resistant cancersresistance to cancer chemotherapy failure in drug response from adme to p gp khalid o alfarouk 1 email author christian martin stock 2 sophie taylor 3 megan walsh 3 abdel khalig muddathir 4 daniel verduzco 5 adil h h bashir 1 osama y mohammed 6 gamal o elhassan 7 8 salvador harguindey 9drug resistance in cancer cells cancer cells can acquire resistance to chemotherapy by a range of mechanisms including the mutation or overexpression of the drug target inactivation of the drug resistance to current chemo and radiation therapy is the principal problem in anticancer treatment although intensively investigated the therapeutic outcome is still far from satisfactory among the multiple factors which contribute to the drug resistance in cancer cells the involvement of autophagy is becoming more and more evident one of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells this is a very serious problem that may lead to recurrence of disease or even death this section is intended to introduce some of the main ways in which cancer cells can resist treatments

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